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Both Isco and Khedira are being linked with January moves away from their respective clubs.
Given Ancelotti’s relationship with the pair, it is hardly surprising that Everton are being linked.
The Italian did not bat back the questions about the pair at his press conference on Friday, but suggested the chances of eitherof them arriving at Goodison Park in January are slim.
“Isco is a rumour from the press, from the media,” Ancelotti said at a press conference ahead of his side’s Premier League clash with Fulham. “It's not a rumour that went out from our side.
"We are not talking about the market in this period, we are talking about the problem that we had and we are working to try and solve this problem.
"Apart from this, Isco was my player at Real Madrid and was a fantastic player. He is a Real Madrid player."
While Isco would add a creative spark to his side, Khedira would be a more combative presence and Ancelotti has fond memories of working with the Germany international.
"I have a good memory of Sami Khedira, he was with me at Real Madrid and was a fantastic professional," Ancelotti said. "I would love to work with him, but unfortunately he's not the only one! I've had fantastic players in my career, I've had good memories of them.
"But to come here to Everton is another thing to consider."
The transfer market will come into focus in the weeks ahead, but the priority for Everton is to get their season back on track.