Please Wait . . .
The hosts' last league defeat came at the hands of Real Madrid on February 1, meaning Los Rojiblancos are unbeaten in their last 23 matches.
Luis Suarez and Lucas Torreira contractedcoronavirus while on duty with Uruguay, whilst Hector Herrera suffered a muscle injury while with Mexico and Stefan Savic also picked up a muscle problem while with Montenegro.
Atletico were already missing Diego Costa and Vitolo Machin, although Yannick Carrasco has returned to fitness and should be available.
Barcelonaare without Sergio Busquets who got injured while away with the Spain national team and Ansu Fati is a long-term absentee having undergone knee surgery.
With both Barcelona and Real Madrid having started the season in underwhelming fashion, Atletico will know they have a great chance to claim only their second league title this century.
It may still be early in the campaign, but Simeone's side have shown the improvement in attack which the signing of Luis Suarez was supposed to bring, while retaining their characteristic defensive strength.
Suarez's absence will be a massive blow for Atletico yet they do boast Joao Felix, who is one of the most in-form players in La Liga, and has been in stunning form.
Indeed, the 21-year-old has six goals in his last five appearances and continued his scoring streak during the international break by netting twice for Portugal.
Barcelona did enda run of four winless league matches before the international break with a 5-2 win over Real Betis, but questions remain about Ronald Koeman's team all over the pitch.
The hosts are offered at 82/100 (1.82) to win with a +0.25 Asian handicap and this looks like a strong selection, which pays out in full if Simeone finally manages to record a league win over Barca, and provides a half win if it ends a draw.
You can watch La Liga live on the go with your iPhone, iPad or Android device through your bet365 account. All you need is a funded account or to have placed a bet in the last 24 hours to qualify.
Odds correct at the time of writing. Please gamble responsibly.