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Barcelona travel to the Estadio Sanchez Pizjuan on Saturday afternoon in La Liga to face a Sevilla side who are just below them in the table.
Julen Lopetegui's men have faced Barca twice this season in competitive fixtures, drawing 1-1 in La Liga at the Camp and beating them 2-0 in the Copa two weeks ago at home.
The hosts are without last-season's top scorer Lucas Ocampos and first-choice left-back Marcos Acuna, while Barca have injured quartetPhilippe Coutinho, Ronald Araujo, Sergi Roberto and Ansu Fati all still unavailable.
It remains to be seen whether both coaches chose to rotate their squad given the upcoming Copa Del Rey semi-final on Wednesday.
The Europa League holders have shown this season that they are one of the best teams in La Liga, with Lopetegui producing a brilliantly-coached unit to prove they can compete with the best sides in the division.
Sevilla generally manage to raise their game when they host Barcelona, winning two and drawing one of their last five meetings in all competitions.
Indeed, the Catalans have won just two of their last six league visits to the Andalusian capital and thereshould be plenty of interest in opposing them this weekend.
The hosts are on a six-match winning streak in La Liga and have kept five consecutive clean sheets, with Barca managing just one goal in their last three competitive matches against Sevilla.
Furthermore, the Blaugrana have been weak defensively - conceding in eight of their last nine clashes in all competitions - and an in-form Sevilla side will surely cause them problems this weekend.
Sevilla to win with a +0.25 Asian handicap at 24/25 (1.96) looks like an excellent option for this game, with this selection paying out in full if the hosts win and providing a half-win if they draw.
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