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Their opponents are a Betis side who have won four and lost four of their opening eight games, although Los Verdiblancoshave managed just three wins in their last 23 away La Liga games.
Betis have won just two of their last 16 matches on the road and bet365 offer them at 7/1 (8.00) to claim a victory in Catalonia.
Marc-Andre ter Stegenshould make his first La Liga appearance of the campaign after recovering from injury, but Ronald Araujo, Samuel Umtitiand Philippe Coutinho are definitely out while Clement Lenglet is a doubt.
The visitors have doubts over centre-back Sideni, midfielder Andres Guardado and forward Juanmi Jimenez,while Victory Camarasa is a long-term absentee.
Wednesday night saw Barca record their third win out of three games in the Champions League to practically assure their place in the knockout stages.
The problem for the Catalans has been a lack of efficiency in front of goal while also conceding regularly and although Ter Stegen should help solidify things, the German was called into action on multiple occasions against a much-weakened Dynamo Kiev side.
Betis have the attacking talent to trouble Barca and there is every chance that this will be a high-scoring encounter as this fixture has regularly been over the last fewyears.
Over 2.5 goals and both teams to score is priced at evens (2.00) and looks an excellent option, with Barcelona conceding in six of their last seven competitive games.
This bet has paid out in each of the last four meetings between these sides and should do once more on Saturday.
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Odds correct at the time of writing. Please gamble responsibly.