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Whether the Blues will be able to challenge for the title remains to be seen, but they are certainly clear favourites to begin the season with a win.
The Seagulls won justfive of their 19 home matches last season, with only bottom club Norwich managing fewer home wins.
These two sides played out a 1-1 draw in a friendly a couple of weeks ago while their most recent competitive meeting back in January also ended in the same scoreline, and another draw can be backed at 10/3 (4.33).
The hosts have doubts over Dutch midfielder Davey Propper who has been struggling with an achilles problem, while Jose Izquierdo and Christian Walton remain out.
Chelsea should give debuts to new signings Timo Werner and Kai Havertz but fellow newcomers Ben Chilwell, Hakim Ziyech and Thiago Silva are all set to miss out, while Mateo Kovacic is suspended.
Despite being separated by 11 places in the table and 23 points, these two sides conceded the same number of goals last season.
Chelsea's total of 54 goals against contributed to their matches being the second most prolific in the division, averaging 3.24 goals, although Lampard will surely be hoping to tighten things up defensively.
On the road, the Blues were the second top scorers and the additions of Werner and Havertz are likely to seriously increase the west Londoners' firepower.
Brighton should be more competitive this season thanks to the addition of Adam Lallana and the emergence of Ben White, but they did struggleat home against the top sides last season, losing3-0 to Manchester United, 3-1 to Liverpool and 5-0 to Manchester City.
Chelsea to win and over 2.5 goals is priced at 7/5 (2.40) and eight of the Blues' nine away wins last term came with at least three goals in the game.
Odds correct at the time of writing. Please gamble responsibly.