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The Eagles endured a dire end to last season, losing seven games in a row after the restart, but it mattered nought as they still survived relegation by nine points.
Southampton were perhaps one of the surprise packages last season as they picked up 15 wins to finish in 11th place and will be looking to build on that further this time around.
Crystal Palace managed just 11 wins last season and bet365 make them 21/10 (3.10) outsiders to start this term with three points.
The Saints won this exact fixture 2-0 back in January and can be backed at 11/8 (2.38) with the online bookmaker.
Two of the last three matches between these teams have finished level and another draw is priced at 9/4 (3.25).
New Palace signing Eberechi Eze looks set to be ready for the opening game despite picking up a groin problem in a friendly last month, while Michy Batshuayi is available after joining the club on loan from Chelsea.
Kyle Walker-Peters should start after joining Southampton permanently last month, whileWesley Hoedt’s future is in doubt amidinterest from Anderlecht.
Every team wants to get off to a good start in the Premier League but it is far from imperative, as Crystal Palace are fully aware.
The Eagles have finished in mid-table in each of their seven top-flight seasons since earning promotion, but they have won just twice and lost four of their opening-day fixtures in that time.
Considering how badly Roy Hodgson’s men ended last season, losing seven and drawing one of their last eight, it is difficult to see them getting anything against a Southampton side that ended last term unbeaten in seven.
Southampton will have loftier expectations than Palace and given how well they finished the 2019-20 season, the 11/8 (2.38) price on an away win with bet365 is the best bet for this fixture.
Odds correct at the time of writing. Please gamble responsibly.