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Nevertheless, they are clear 4/9 (1.44) favourites with bet365 to return to bounce back by coming out on top on home turf.
Last Friday’s Coupe de la Ligue final penalty shootout defeat against PSG was Les Gones’ first competitive match since March, and they are 13/2 (7.50) outsiders to blow off the cobwebs with a shock win here.
The visitors claimed a creditable 1-1 draw in their last visit to this stadium back in 2016, and you can get odds of 7/2 (4.50) on them booking a place in the quarter-finals by holding out for a stalemate once again.
Paulo Dybala will face a late fitness test as he recovers from a thigh injury, while Matteo De Sciglio and Douglas Costa are both ruled out.
Youssouf Kone is injured and Kenny Tete and Marcelo both doubtful, although Memphis Depay is available once again after missing the first leg due to injury.
Despite extending their Scudetto-winning streak to nine in a row, the Bianconeri have not been entirely convincing this season - particularly in defence.
Their record of 43 goals conceded in 38 Serie matches this season is their worst since 2011, which wasthe last time they failed to lift the title in a disappointing campaign that saw them way down in seventh.
Having kept just one clean sheet in their 10 last matches of the league season - losing three of the final four - they look vulnerable to a Lyon attack that has scored in eight of their previous nine Champions League away matches.
Indeed, odds of 10/11 (1.91) seem generous on both teams finding the net for Juventus’ ninth match in 11, as well as a seventh Champions League away game in 10 for Rudi Garcia’s side.
Odds correct at the time of writing. Please gamble responsibly.