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Their loss in Belgium last week remains Spurs' only defeat in their last 12 matches, with Mourinho's side particularly strong domestically.
The manager is expected to rotate his squad on Thursday night but the Premier League outfitare nevertheless highly fancied, priced at 1/3 (1.33)with bet365.
Spurs have no major injury concerns, butHarry Kane and Son Heung-min are yet to start a game in the group stages and are likely to be on the bench once more along with the likes of Toby Aldeweireld and Pierre-Emile Hojbjerg.
The Bulgarians will be without their top scorer this season in Higinio Marin, with the Spaniard suffering a serious knee injury.
Last week's performance in Belgium was one of the poorest of the season from Tottenham and Mourinho will expect much better from his side even if he does rotate the squad.
There are still defensive issues for the north Londoners to address, though, and just two clean sheets in 13 competitive fixtures so far this term underline the work that is still to be done.
Ludogorets have scored in each of their last 10 games in all competitions including in both of their group games so far, andwill be lookingto takeadvantageof Spurs' poor record at the back.
The Bulgarian champions have also netted in nine of their last 12 Europa League matches, including qualifiers,and last season they scored in five of their six group games as well as at Inter in the knockout stages.
Odds correct at the time of writing. Please gamble responsibly.