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With European success the one achievement still eluding them, they are priced at 2/9 (1.22) with bet365 to take the first step towards rectifying that by coming out on top.
Porto are back after failing to qualify for the group stages for the first time in 17 years last season and can be backed at 10/1 (11.00) to make up for lost time with a shock victory here.
Just one of the hosts’ last 20 home matches has resulted in a draw, but there are odds of 11/2 (6.50) on this one finishing up all square.
Aymeric Laporte, Gabriel Jesus, Kevin De Bruyne, Benjamin Mendy and Oleksandr Zinchenko are all ruled out through injury.
Reserve goalkeeper Mouhamed Mbaye is the only injury absentee for the visiting side, with Mateus Uribe and Luis Diaz having recovered in time for Saturday’s draw with Sporting.
Despite their respectable European pedigree, Sergio Conceicao’s team doesn’t arrive in Manchester in particularly strong shape.
Forced to offload a number of top earners and promising youngsters over the summer due to financial difficulties, they have won just two of their opening four domestic league matches - conceding five times in the last two.
This doesn’t bode well for a match against a Citizens outfit that has scored 30 times in their last nine home matches in this competition, winning eight.
In fact, odds of 6/4 (2.50) look well worth backing on City easing to victory by three clear goals against a Porto side that has won just twice in eight away games in this competition.
All odds correct at time of writing. Please gamble responsibly.