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However, they are 5/2 (3.50) outsiders with bet365 to take a big step towards delivering the manager’s first piece of silverware by coming out on top against the local rivals.
The Citizens have lifted this trophy in four of the last five seasons and are even money (2.00) favourites to take their place in the final once again with a victory here.
These sides shared a 0-0 draw when they met at this ground in last month’s tepid Premier League encounter, and you can get odds of 14/5 (3.80) on them taking this clash into extra-time with another deadlocked 90 minutes.
Victor Lindelof is doubtful and Marcos Rojo injured, while quarter-final hero Edinson Cavani is suspended.
Ederson, Kyle Walker, Eric Garcia, Ferran Torres and Gabriel Jesus are all set to miss out because of COVID-19, with Aymeric Laporte a doubt due to injury.
Although their opponents’ recent record in this competition is fairly daunting, the Red Devils will still be in a confident mood going into this match.
In high spirits after underlining their league title credentials with an impressive run of results, Solskjaer's side also boast a very creditable record in recent derby matches - winning three and losing just one of the last five.
While the Citizens are also in good shape in terms of results, they do arrive on enemy territory without a number of first-team players due to a spate of positive COVID-19 tests.
With just 10 goals to their name in the last eight matches on the road, it is hard to see them outscoring a prolific home side they have failed to fire past in any of the last three meetings.
In fact, odds of 8/11 (1.73) seem generous on United at least taking the match into extra-time by avoiding defeat in 90 minutes against City.
All odds correct at time of writing.Please gamble responsibly.