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Sweden, meanwhile, are bottom of the group after three successive defeats but may be in good spirits after claiming a 2-1 friendly win over Russia last week.
Portugal have not lost a competitive game on home soil since 2014, although they did lose 3-2 when Sweden visited in a friendly three years ago.
The hosts are without goalkeeper Anthony Lopes and star forward Cristiano Ronaldo after they bothed tested positive for coronavirus.
Sweden defender Filip Helander has left the squad with an injury.
This will be the fifth meeting between these two nations in the last seven years, with the most recent clash seeing Portugal win 2-0 last month thanks to a brace from Cristiano Ronaldo.
The Portuguese have a strong scoring record at home, understandably given the array of attacking talent they possess, while Sweden are yet to keep a clean in this edition of the Nations League.
Therefore, backing the hosts to score looks like an appealing prospect with Portugal nettingat least twice in five of their last eight clashes against Sweden.
Portugal to win and score over 1.5 goals is priced at 5/6 (1.83) and looks like a shrewd angle from which to approach backing a home win.
Odds correct at the time of writing. Please gamble responsibly.