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The teams look evenly matched on paper, although perhaps Sevilla's greater experience in the competition is one of the reasons why they are clear favourites at 6/5 (2.20) to win in 90 minutes with bet365.
Julen Lopetegui will be without a couple of players who were crucial during the league season, with midfielder Ever Banega having left the club and full-back Sergio Reguilon's loan deal having ended. Goalkeeper Tomas Vaclik is a major doubt while Nemana Gudelj's is out.
Roma are without injured duo Antonio Mirante and Lorenzo Pellegrini, while Chris Smalling's loan has finished and midfielder Jordan Veretout is suspended.
Sevilla are unbeaten in their last 17 matches in all competitions and showed themselves to be one of the best teams in La Liga over the course of the 2019/20 season.
There were a few questionmarks surroundingSevilla'seffectiveness in the final third this term,yet they still managed to score in nine of their 11 games following the restart.
Roma, meanwhile, ended the campaign in blistering fashion, scoring more goals and picking up more points than any other Serie A side in the last six games of the competition.
The Italian side have plenty of momentum heading into this clash and it is possibly in their favour that their league season ended on Sunday while Sevilla have not played sinceJuly 19.
As well, they scored at least twice in each of their last eight encounters of their league campaign and there should be goals when the sides meet on Thursday.
Odds correct at the time of writing. Please gamble responsibly.