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A draw would see the tie go into extra time and potentially penalties, and that result is also available at 11/4 (3.75) with the online bookmaker.
Davit Khocholava is suspended after being sent off in the last-16 tie against Wolfsburg, which means Serhii Bolbat could deputise.
Basel also have a player suspended after Eray Comert picked up a booking against Frankfurt, whilst Jonas Omlin, Ramires and Luca Zuffi are all injured.
It is not a surprise to see Shakhtar as odds-on favourites for this clash considering Basel have struggled for consistency since the resumption of the Swiss Super League in June, winning just one of their last five matches to finish 14 points off the pace.
Shakhtar have seemingly suffered no ill-effects of the prolonged break, winning seven and drawing two of their final nine domestic fixtures as well as seeing off Wolfsburg 3-0 in the previous round of the Europa League.
The recent form of the Ukrainian champions makes it difficult to oppose them in this clash, especially considering Basel have scored just once in their last three games and could find it difficult to break down a fairly stoic Shakhtar defence.
With that in mind, the 10/11 (1.91) price from bet365 on Shakhtar to book a Europa League semi-final place against Inter offers good value for punters ahead of this clash.
Odds correct at the time of writing. Please gamble responsibly.