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Alvaro Morata has been recalled to the Spain squad, along with Koke, while Marcos Llorente has earned a first senior call-up.
Morata's last appearance for Spain was in a 5-0 Euro 2020 qualifying win over Romania in November 2019.
Enrique told his press conference on Friday:"I am not worried. I call on Morata because since he returned toJuventus hehas been confident and his numbers indicate it, and he has an attitude bothin attack and defense as I like it.
"Those of us who have watched him can appreciate that in terms of confidence and performance, heis better than the previous Morata, but it is a question for him."
Atletico Madrid midfielder Koke has also returned, having last played for his country in a 4-1 friendly defeat of Wales more than two years ago. Team-mate Llorente has earned his first call-up, while Liverpool's Thiago Alcantara is out due to problems with a knee injury and Arsenal's Dani Ceballos has been omitted.
With Diego Llorente injured, Inigo Martinez returns, as does Fabian Ruiz. Rodrigo Moreno is left out after testing positive for coronavirus this week.
Chelsea goalkeeper Kepa Arrizabalaga keeps his place despite having lost his starting spot under Frank Lampard to new signing Edouard Mendy.