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This is the 17th game that Wolves will be playing in this season's Europa League, a campaign which began in the qualifying rounds over a year ago.
Wolves are unable to call upon the services of Jonny Castro with the full-back picking up an injury in their previous game, while Daniel Podence is also unavailable through suspension.
Sevilla have a clean bill of health with only Serbian midfielder Nemanja Gudelj missing.
Sevilla showed themselves to be one of the best teams in Spain over the courseof the La Liga season and their impressive domestic form was followed upwith a European masterclass against Roma.
Lopetegui's team are extremely well coached, defensively organised, capable of dominating possession and dictating the tempo of a game.
They are also high on confidence as they have not lost a game since February and Sevilla will certainly fancy their chances against a Wolves team that were beaten in three of their last six Premier League clashes.
Wolves' only two defeats in the competition have come against sides from the Iberian Peninsula -going down to Braga and Espanyol, respectively- and backing them lose once again should hold plenty of interest.
Odds correct at the time of writing. Please gamble respnsibly.