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Marchisio, who spent 25 years in the Juve system and played with Pogba during the Frenchman's stint in Turin between 2012-16, believes his former protege can achieve happiness if he comes back to Juventus Stadium.
Along with Real Madrid, Pogba's former club have been consistently linked with a transfer for the midfielder in recent years, with the France international struggling for consistency in his second stint at Old Trafford.
His national team boss Didier Deschamps believes the struggles Pogba is having atManchester United are affecting his performances at international level.
"He’s not in his best form, of course. I knew that before the game,” Deschamps told the media after France's 2-0 loss to Finland.
"This match was meant to give him some rhythm. He knew that he would only play for an hour.
"It’s hard to remember to be positive. Obviously, he’s not in one of his better periods.
"Like all players who have a club situation that is not positive, they are also impacted mentally. I know him well enough and it can happen at some points.”
Pogba has appeared for Manchester United in 11 matches this season, but six of them have been as subsitute appearances, with Bruno Fernandes preferred in an attacking midfield role and Scott McTominay and Fred selected as the holding midfielders.
He admitted to going through the most 'difficult' period of his career in England, but revealed his time with France has been a welcome relief.
"I had never known such a difficult period in my career," he said in an interview withRTL.