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The Premier League outfit are one of the shortest-priced favourites in the third round of the FA Cup, offered at just 3/25 (1.12) by bet365 to claim a win.
An outbreak of coronavirus among City's squad means Ferran Torres, Ederson and Eric Garcia are all unavailable, along with youngsters Tommy Doyle and Cole Palmer, and veteran Scott Carson.
Muscle injuries for Aymeric Laporte and Nathan Ake also make them unlikely to feature.
Meanwhile, Aitor Karanka is set to be without the services of injured midfield duo Gary Gardner and Alen Halilovic.
An upset at the Etihad Stadium this weekend looks far from probable, with City's form contrasting heavily with that of their opponents.
Guardiola's men have racked up five consecutive wins in all competitions and are unbeaten since November, while Birmingham are winless in their last six matches, of which they have lost five.
It remains to be seen how seriously the visitors take the clash given they are hovering above the relegation zone and clearly have their priorities elsewhere.
Guardiola of course may well rotate his squad given the packed fixture schedule, yet nevertheless City should still be far too strong for a Birmingham team that have managed just 17 goals in 23 Championship games this season.
All odds correct at time of writing. Please gamble responsibly.
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