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"Our previously postponed home fixture against Fulham, originally scheduled for 30 December 2020, will now take place on the same evening (Wednesday 13 January), kick-off 8.15pm on Amazon Prime Video.
"The Premier League informed us of the decision following a request by Aston Villa on the grounds of the number of their players and staff who have either tested positive for Covid-19 or have been placed in isolation.
"Everyone at Tottenham Hotspur sends their best wishes to Aston Villa for a safe and speedy recovery to all those who are affected.
"Details of a new date for our match at Villa Park will be confirmed in due course."
Villa were hit with a significant outbreak of coronavirus among squad and staff members last week, leaving Smith with only youth-team players to call upon in a third-round FA Cup tie against Liverpool on Friday - which they ended up losing 4-1.
The number of cases at the club remains too high for their latest Premier League outing to go ahead, meaning Tottenham are having to deal with their second fixture postponement in the space of two weeks.
Fulham, meanwhile, have also seen a meeting with Chelsea that was originally scheduled for Friday pushed back by a day so that they have more time to prepare after their encounter with Spurs.
Jose Mourinho's men will be expected to pick up three points against the Cottagers on home turf after opening their latest FA Cup campaign with a5-0 thrashing of eight tier outfit Marine at the weekend.